Polynucleotides
Treatment Areas
Skin
Polynucleotides are a regenerative medicine tool, not a ‘skin booster’.
Polynucleotides work on a cellular level to repair tissue and boost skin quality.
They are an exciting development in aesthetic medicine, providing us with an innovative treatment for skin rejuvenation, wrinkle reduction, and enhanced skin quality.
Common uses for Polynucleotides
- Fine lines in the eye area
- Acne scarring
- Dark under-eye circles
- Skin laxity
- Poor skin tone and texture
- Scalp and eyebrow hair quality
- Red, sensitive skin
- Rosacea
- Stretch marks
- Scars
- Décolletage rejuvenation
- Upper arm skin quality
- Saggy / crepey neck skin
- Dry skin / eczema
- Hyperpigmentation / sun damaged skin
Regenerate your skin from within using the power of polynucleotides.
The polynucleotides used in this clinic are manufactured in Italy by Mastelli using High Purification Technology (PN HPT™). These are natural, not synthetic products, obtained through technology that involves a high degree of purification and safety checks.
The Benefits of Using Polynucleotides
Polynucleotides are the building blocks of DNA and RNA. These are nucleic acids that give the instructions for cell function, regeneration and gene expression.
They have been used in medicine since 1986, to promote wound healing and tissue repair, with over 50 scientific publications in the last 20 years.
Polynucleotides are extracted from Salmon or Trout, sterilised and ultra-purified before being made into injectable products. As polynucleotides are broken down in our body, they promote DNA synthesis, stimulate fibroblasts, increase cell regeneration and turnover, cellular repair and the production of collagen and elastin whilst reducing inflammation. They also protect against harmful external agents such as UV rays.
Their anti-inflammatory properties along with the ability to rebalance melanocyte activity creates an even and refreshed skin tone.
The polynucleotides used in this clinic are manufactured in Italy by Mastelli using High Purification Technology (PN HPT™). These are natural, not synthetic products, obtained through technology that involves a high degree of purification and safety checks.
Skin Regeneration
Polynucleotides stimulate cell growth and proliferation, enhancing collagen and elastin production which are necessary for skin elasticity, firmness, and lift.
Wrinkle Reduction
They aid in reducing fine lines and wrinkles and improve skin texture and smoothness by promoting the formation of new skin cells and enhancing overall skin health.
Skin Hydration
They exhibit hydrating properties and improve the skin’s ability to retain water, promoting healthier and more supple skin.
Anti-inflammatory Effect
They can soothe and calm skin, reducing redness, irritation, and inflammation caused by various skin conditions, including acne, eczema, hyperpigmentation, and rosacea.
Hair Growth Promotion
trophic action on hair and eyebrows.
Various Skin Concerns
Polynucleotides can be a potential treatment for individuals with fine lines, wrinkles, loss of elasticity, red and sensitive skin, rosacea, and scarring.
Cellular Turnover and Healing
They promote cell turnover, improve skin elasticity and hydration, and help heal sun-damaged skin, photoaging, and scars.
Skin preparation
Polynucleotides also make skin more receptive to other medical, aesthetic, and anti-ageing treatments such as laser, fillers, chemical peels, micro-needling, and surgery.
Plinest Eye
Mastelli Skin Priming Line
Patients frequently request aesthetic treatments for the periorbital area to look more refreshed and less tired as well as treat wrinkles, crow’s feet and even drooping of the upper eyelids. Combining efficacy and safety, low-concentration PN HPT™ formulations are recommended for the sensitive facial skin and other delicate skin areas (eg. periorbital area).
The Plinest Eye concentration allows the improvement of fibroblast activity without causing excessive pulling or oedema / swelling. The thin periocular skin is an area where Plinest Eye appears to offer distinctive aesthetic outcomes.
Tightening of the eye area skin visibly improves, including the most severely sagging areas. Research carried out by Mastelli showed that over 90% of patients experience clinical improvement in the reduction of fine, superficial wrinkles as well as an improved skin appearance using their treatment protocol.
The results were also confirmed by objective evaluations using 3D skin analysis.
90%
Patients Experience Clinical Improvement
Plinest Hair
Mastelli Skin Priming Line
Further research carried out by Mastelli has shown that this product has clinically proven safety and efficacy for stimulation of the scalp to promote hair growth in cases of female hormonal hair loss.
20 female patients aged between 25 and 65 years suffering from non-androgen-dependent female hormonal alopecia who were not suffering from systemic diseases (iron deficiency, febrile diseases, endocrinopathies, liver diseases) and with no current or recent psycho-physical stress, weight loss diets, drug therapy, contraceptive pills (all of these can affect hair loss / growth) Plinest Hair was administered and clinically evaluated.
The female alopecia objectively improved in 72% of treated women with no side effects and high patient’s compliance. Video dermoscopy demonstrated an increase in the number of average number of hairs in a standard area before and after treatment at 4 months.
72%
Female Alopecia Improvement
Patients Journey
Appointment Duration
30-40mins
Initial Treatment
3-4 treatments, 2-4 weeks apart
Anaesthetic
Local anaesthetic cream may be used.
Maintenance
3-6 monthly
FAQs
Frequently Asked Questions
Are polynucleotides safe for everyone?
There are virtually no medical contraindications to Polynucleotides.
Are polynucleotides vegan friendly?
They are not vegan friendly.
How long do polynucleotides last?
Typically, the effects of these treatments last 6 to 12 months. Regular treatments can provide more noticeable and long-lasting results.
Are polynucleotides skin boosters?
No. We may advise the use of a combination of skin boosting hyaluronic injections, hyaluronic acid with collagen stimulators, as well as polynucleotides depending upon what we are treating. We can discuss this with you at a skin assessment consultation.
What are the risks of polynucleotides?
Risks are usually minimal and may include temporary redness, or mild discomfort at the injection site. As these treatments use naturally derived substances, the risk of allergic reactions is significantly reduced.
What type of polynucleotide is right for me?
The best type of polynucleotide will depend on your specific skin concerns, skin type, and desired results. This will be discussed during your consultation.
We may advise the use polynucleotides when patients don’t want ‘filler’ or simply don’t need volume replacement.
The area around the eye can be improved with polynucleotides which can be great for this tricky to treat area avoiding the need for a filler product.
NEWEST© is a novel product that contains hyaluronic acid as well as polynucleotides. This can be extremely useful when the goals are smoother, plumper skin with the added benefit of tissue repair.
What is the technique for the treatment?
The treatment protocol for polynucleotides involves a series of injections under the skin that may involve use of a blunt tipped cannula. The specific application techniques and protocol may vary depending on the area being treated, the individual’s skin type, treatment goals, and the specific product being used.
Treatment Pricing
Individualised plans are made based on a clinical assessment and volume recommended will vary for each patient.
Appointments
To book an appointment please use the online Booking Form
Booking Form
Or call us on
0800 464 7220
Consultations can be in person in Newcastle upon Tyne or online if you do not live locally or would prefer a video consultation.
If you are unsure whether this service is right for you then a free discovery call can be arranged. Please request this using the Booking Form.
To book a consultation, please use the Booking Form and select which service you would like.
If you live outside the North East and require blood tests, they can be taken at or close to home.
Trish is a Treasure and has done, for (ageing) me, some excellent work. It is so reassuring to be able to have confidence in her well-qualified hands and where everything is so relaxing, within her beautiful surroundings. Trish listens, offers advice and is so versatile. Highly recommended.
I saw Trish in February of this year, as I was really struggling to manage some really unpleasant symptoms of menopause. I really wanted a holistic individualised approach, as opposed to a one size fits all. I was so frustrated that the more conventional treatments weren't working for me, and began to feel that I was beyond help. I found my appointment with Trish an absolute eye opener, because of her attention to detail, her interest in me as a person, and her assessment of my history. All of this, helped her devise a plan for me that has really worked. I still have blips, but my family have noticed the change in me for the better. Trish is contactable, and has helped me with advice and support following my appointment for which I am so grateful for. I would highly recommend her to anybody who is struggling with menopause, and the many challenges that come along with it.
So knowledgeable and welcoming. We talked through everything so I felt I made the right decision and knew everything i needed to. Really lovely service and I was made to feel at ease. Defo recomend. I will be back!
I first met Trish last year when I sought advice about ongoing menopausal issues. Trish has a thorough understanding of the menopause, her knowledge is up to date and her compassion is evident. I had some worrying symptoms that my GP felt did not warrant investigation but Trish provided me with a clear and concise assessment which my NHS GP took on board. This resulted in prompt action and subsequent treatment on the NHS which without her expertise I would not have had access to. To say I am grateful is an understatement! To say thank you really doesn’t seem to do justice to the support Trish provided, but thank you again. I would highly recommend Trish and I would not hesitate to seek her advice again if needed.
Another amazing treatment from Dr. Trish. This one to dramatically reduce the appearance of fine lines above the top lip. Super pleased with the result including the look of the lips themselves (which I confess I was slightly concerned about). All of my treatments have been planned really carefully through a lot of discussion and I could not be happier with the results.
I have been going to Trish for my HRT as well as other anti-ageing treatments such as Obagi skincare and Botox for over a year. Imo she is a formidable ally for us pre/post and menopausal lasses: she took time to investigate my concerns, helped me sort out my HRT regiment according to my personal situation, which my GPs neither have the time nor resources to, and she keeps my treatment regiment monitored. I even got my husband signed up for Trish's HRT treatment and he's doing really well as well. I also totally trust Trish to do my Botox treatments - she's very gentle in her touch, precise in her dosing and clearly understands the facial anatomy better than many other practitioners not very thoroughly trained in the subject of human anatomy. I wouldn't go anywhere else.
DR Trish is a super understanding woman . I've been seeing her for a year . I was on Antidepressants which have I've suffered on them . Dr Trish said I need hrt not AD. I have tried a few hrt and with tweaks here and there I'm starting to feel better slowly. Worth every penny. Thankyou Dr Trish 😘
My consultation with Dr Trish Davis was completely reassuring and reaffirming. It is clear she is incredibly passionate and knowledgeable about her field, and incredibly thorough in her review of me as an individual. Dr Davis was exceptionally patient and understanding, and took the time to really understand my circumstances and tailor an HRT treatment plan to suit me.I left the appointment feeling heard, validated and positive about my next steps with HRT.I believe every women should be afforded that right and 100% recommend Dr Trish Davis.
